Eggehard Holler Selected Research

malic acid (malate)

1/2019	Blood-brain barrier permeable nano immunoconjugates induce local immune responses for glioma therapy.
12/2013	Toxicity and efficacy evaluation of multiple targeted polymalic acid conjugates for triple-negative breast cancer treatment.
1/2012	Cellular delivery of doxorubicin via pH-controlled hydrazone linkage using multifunctional nano vehicle based on poly(β-l-malic acid).
11/2010	Temozolomide delivery to tumor cells by a multifunctional nano vehicle based on poly(β-L-malic acid).
10/2010	Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected].
1/2010	Nanoconjugate Platforms Development Based in Poly(β,L-Malic Acid) Methyl Esters for Tumor Drug Delivery.
10/2007	Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid).
3/2006	Polycefin, a new prototype of a multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Eggehard Holler Research Topics

Disease

30	Neoplasms (Cancer) 10/2021 - 01/2006
12	Glioma (Gliomas) 11/2020 - 01/2006
10	Brain Neoplasms (Brain Tumor) 10/2021 - 01/2006
10	Breast Neoplasms (Breast Cancer) 01/2017 - 01/2005
4	Glioblastoma (Glioblastoma Multiforme) 10/2021 - 01/2006
3	Alzheimer Disease (Alzheimer's Disease) 09/2015 - 10/2010
2	Nervous System Diseases (Neurological Disorders) 01/2019 - 10/2010
2	Triple Negative Breast Neoplasms 12/2013 - 01/2012
1	Hyperthermia 10/2020
1	Inflammation (Inflammations) 01/2018
1	Amyloid Plaque 09/2015
1	Lung Neoplasms (Lung Cancer) 05/2015
1	Infections 03/2015
1	Hemorrhage 03/2015
1	Multiple Sclerosis 10/2010
1	Carcinoma (Carcinomatosis) 01/2005

Drug/Important Bio-Agent (IBA)

14	Pharmaceutical PreparationsIBA 10/2020 - 10/2007
13	poly(malic acid)IBA 01/2019 - 01/2006
11	Antisense OligonucleotidesIBA 01/2017 - 01/2006
8	malic acid (malate)IBA 01/2019 - 03/2006
8	NanoconjugatesIBA 01/2019 - 03/2006
6	PolymersIBA 10/2021 - 01/2008
6	polycefinIBA 11/2013 - 01/2006
5	Transferrin Receptors (Transferrin Receptor)IBA 03/2012 - 01/2006
5	MorpholinosIBA 01/2012 - 01/2006
4	AntibodiesIBA 01/2019 - 10/2007
4	Proteins (Proteins, Gene)FDA Link 12/2013 - 10/2007
4	Monoclonal AntibodiesIBA 01/2012 - 03/2006
3	Immunoconjugates (Immunoconjugate)IBA 11/2020 - 01/2019
3	Contrast MediaIBA 01/2020 - 05/2015
3	Biopolymers (Biopolymer)IBA 01/2019 - 03/2006
3	Peptides (Polypeptides)IBA 01/2019 - 03/2012
3	laminin 8IBA 10/2007 - 01/2006
2	epidermal growth factor receptor VIIIIBA 10/2021 - 12/2016
2	GadoliniumIBA 01/2020 - 09/2015
2	ErbB Receptors (EGF Receptor)IBA 12/2016 - 12/2013
2	CurcuminIBA 09/2015 - 09/2015
2	Fluorescent Dyes (Fluorescent Probes)IBA 02/2012 - 03/2006
2	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2012 - 01/2012
2	Nucleosomes (Nucleosome)IBA 01/2012 - 10/2007
2	EstersIBA 10/2010 - 01/2010
2	Laminin (Merosin)IBA 03/2006 - 01/2005
1	ferric oxide (iron oxide)IBA 10/2020
1	ChlorotoxinIBA 01/2019
1	CTLA-4 AntigenIBA 01/2019
1	NestinIBA 01/2019
1	Indocyanine Green (Cardio-Green)FDA LinkGeneric 01/2019
1	Particulate MatterIBA 01/2018
1	Tumor Biomarkers (Tumor Markers)IBA 01/2018
1	Biological ProductsIBA 01/2017
1	Nanoparticle Drug Delivery SystemIBA 01/2017
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 12/2016
1	Retinaldehyde (Retinal)IBA 09/2015
1	Glatiramer Acetate (Copaxone)FDA Link 09/2015
1	gadolinium 1,4,7,10- tetraazacyclododecane- N,N',N'',N'''- tetraacetateIBA 05/2015
1	Interleukin-2 (IL2)IBA 11/2013
1	CytokinesIBA 11/2013
1	Oncogene Proteins (Oncogene Protein)IBA 11/2013
1	Immunoglobulin G (IgG)IBA 11/2013
1	MicellesIBA 11/2013
1	Dendrimers (Dendrons)IBA 11/2013
1	CarbonIBA 11/2013
1	Liposomes (Liposome)IBA 11/2013
1	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 02/2012
1	LigandsIBA 02/2012
1	Biotin (Vitamin H)FDA Link 02/2012
1	poly(benzyl malate)IBA 02/2012
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 01/2012
1	HydrazonesIBA 01/2012
1	Trastuzumab (Herceptin)FDA Link 02/2011
1	ErbB-2 ReceptorIBA 02/2011
1	Messenger RNA (mRNA)IBA 02/2011
1	ProdrugsIBA 11/2010
1	Alkylating AgentsIBA 11/2010
1	A-Form DNA (A-DNA)IBA 11/2010
1	Temozolomide (Temodar)FDA LinkGeneric 11/2010
1	leucyl-leucyl-leucineIBA 10/2010
1	Leucine (L-Leucine)FDA Link 10/2010
1	S 6 (S-6)IBA 03/2006
1	Valine (L-Valine)FDA Link 03/2006
1	Biomarkers (Surrogate Marker)IBA 03/2006
1	DisulfidesIBA 03/2006
1	Ethylene Glycol (Monoethylene Glycol)IBA 03/2006
1	OligonucleotidesIBA 03/2006
1	Protein Isoforms (Isoforms)IBA 01/2005

Therapy/Procedure

10	Therapeutics 11/2020 - 01/2005
2	Intravenous Injections 01/2020 - 10/2007
2	Drug Therapy (Chemotherapy) 01/2012 - 01/2012
1	Immunotherapy 09/2015
1	Bandages (Bandage) 03/2015
1	Precision Medicine 06/2014
1	Ligation 06/2014
1	Injections 01/2008
1	Subcutaneous Injections 01/2008